NFL Week 10 upset picks: New York Giants have realistic shot in San Francisco

Week 10 in the NFL is not a week for close games. As of Wednesday night, every single game on the schedule had a line of at least three points. That means every game this week is eligible to be chosen as our Upset Watch for the week. But for the game that we think is the most likely upset, you have to wait all the way to the end, when Monday Night Football airs on ESPN.

Lines courtesy of the Westgate Las Vegas SuperBook, as of Thursday morning.

Upset watch: New York Giants at San Francisco 49ers (-3)

Nationally televised games can do a lot to influence our perception of NFL teams. Most fans, when they think of the New York Giants right now, think of their embarrassing 34-13 loss at home to Philadelphia four weeks ago, nationally televised on a Thursday night. When they think of the San Francisco 49ers right now, they think of last week’s 34-3 drubbing of Oakland, also on national television on a Thursday night.